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There are several amazing odd ball calibers for hunting rifles. The 25-06 is great along with 243, 240, 6mm....etc. Buy a caliber that has several ammunition manufacturers and the ammunition is readily available. Personally I have 300 WSM and its an amazing round but I RARELY ever find a store with more than one box of 300 WSM and its over priced by 20%.

Stick with the common calibers unless you hand load your own stuff.

Wratherby generally makes a very nice firearm.

Depending on what grain bullet you want to shoot, either the 243 or 270 should fix your need for a flat shooting antelope gun. And the 7mm is the ultra flat shooting 27 caliber. All of these are pretty easy to find ammo and relatively cheap too.

I shoot the 243 for antelope but own pretty much everything listed above. All are great calibers. My personal favorite is the 243. I shoot hogs, deer and anteleope with a 100 grain lead bullet. So far out of about 25 animals none have ran off.
 

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I've been shooting a 25-06 for years. I've never had an issue with finding ammo for it. It's a great caliber for what you are wanting to do with it. Good luck!
 

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I've read more than once that the .25-06 is the perfect antelope rifle. I hunt with several friends and have seen them take whitetails, antelope and Mulies from 50 to 300 ish yards with no problems. I hand load for them and really like the classic Hornady interlock boat tail, but they shoot similar style bullets off the shelf about as well-federal fusion and Remington core lokt. Remember they are shooting antelope and deer
 

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25-06 is a great deer/antelope round. Somewhat versatile in terms of bullet weights, can go from 85 gr to 117 gr. Good trajectory but even with heavy loads is not good past 400 yds for deer and I've been told it is adequate on cow elk at reasonable ranges. I have three 25-06s and agree that it is a great deer round, and that there are lots of good rounds today in the 6-7mm range or 240-280 range.
 

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I have a mod 70 featherweight in 280 cal that was my Dad's. Only drawback is ammunition availability, and that's a fairly common caliber. If you reload this isn't so much an issue. If you do not reload, consider .270 or 30.06 for practicality sake ... ammo almost everywhere.
 

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johnsd16 said:
25-06 is a great deer/antelope round. Somewhat versatile in terms of bullet weights, can go from 85 gr to 117 gr. Good trajectory but even with heavy loads is not good past 400 yds for deer and I've been told it is adequate on cow elk at reasonable ranges. I have three 25-06s and agree that it is a great deer round, and that there are lots of good rounds today in the 6-7mm range or 240-280 range.
In my opinion, unless your shooting in flat areas with little to no vegetation - or you have a spotter watching while you shoot to mark the spot when you go to look for signs of a hit, long shots past 400 yards are unethical. Shots at 100 yards in the mountains, hunting alone, are difficult enough just trying to find where the animal was when you let loose.

Often as not, elk or deer may go straight down ... or run 100 yards.
 
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